Citicoline eye drops studies

• Vernazza S. et al. Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model. Int J Mol Sci 2022 Sep; 27;23(19):11375 – read more
• Rossetti L. et al. Can Treatment With Citicoline Eyedrops Reduce Progression in Glaucoma? The Results of a Randomized Placebo-controlled Clinical Trial. J Glauc 2020 Jul; 29(7):513-20 – read more
• Carnevale C. et al. Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution. PLoS One. 2019; 14(11): e0224982 – read more
• Parisi V. et al. Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study. Adv Ther (2019) 36:987–996 – read more
• Bogdanov P. et al. Effects of Liposomal Formulation of Citicoline in Experimental Diabetes-Induced Retinal Neurodegeneration. Int. J. Mol. Sci. 2018, 19, 2458 – read more
• Parisi V. et al. Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma. Graefes Arch Clin Exp Ophthalmol.2015 Aug;253(8):1327-40 – read more
• Roberti G. et al. A preliminary study of the neuroprotective role of citicoline eye drops in glaucomatous optic neuropathy. Indian J Ophthalmol. 2014 May;62(5):549-53 – read more
• Parisi V. et al. Citicoline and Vitamin B12 Eye Drops in Type 1 Diabetes: Results of a 36-Month Pilot Study Evaluating Macular Electrophysiological Changes. Adv Ther 2021 Jul; 38(7):3924-3936 – read more
• Fogagnolo M. et al. Topical citicoline and vitamin B12 versus placebo in the treatment of diabetes-related corneal nerve damage: a randomized double-blind controlled trial. BMC Ophthalmol. 2020;20:315 – read more
• Parravano M. et al. Citicoline and Vitamin B12 Eye Drops in Type 1 Diabetes: Results of a 3-year Pilot Study Evaluating Morpho-Functional Retinal Changes. AdvTher (2020)37:1646–1663 – read more
• Maestroni S. et al. In vivo Evaluation of Retinal and Choroidal Structure in a Mouse Model of Long-Lasting Diabetes. Effect of Topical Treatment with Citicoline. Journal of Ocular Diseases and Therapeutics, 2015, 3, 1-8 – read more
• Matteucci A. et al.  Neuroprotective Effects of Citicoline in in Vitro Models of Retinal Neurodegeneration. Int. J. Mol. Sci. 2014, 15, 6286-6297 – read more

Citicoline oral solution studies

• Rossetti L. et al. The effect of citicoline oral solution on quality of life in patients with glaucoma: the results of an international, multicenter, randomized, placebo-controlled cross-over trial. Graefes Arch Clin Exp Ophthalmol. 2023 Jun; 261(6):1659-1668 – read more
• Sbardella D. et al. Structural and functional evidence for citicoline binding and modulation of 20S proteasome activity: Novel insights into its pro-proteostatic effect. Biochem Pharmacol 2020 Jul; 177:113977 – read more
• Lanza M. et al. Morphological and Functional Evaluation of Oral Citicoline Therapy in Chronic Open-Angle Glaucoma Patients: A Pilot Study With a 2-Year Follow-Up. Front Pharmacol. 2019 Sep 26;10:1117 – read more
• Parisi V. et al. Neuroenhancement and neuroprotection by oral solution citicoline in non-arteritic ischemic optic neuropathy as a model of neurodegeneration: A randomized pilot study. PLoS One. 2019 Jul 26;14(7):e0220435 – read more
• Ottobelli L. et al. Citicoline Oral Solution in Glaucoma: Is There a Role in Slowing Disease Progression? Ophthalmologica 2013;229:219–226 – read more

Reviews

• Oddone F. et al. Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review. Pharmaceuticals (Basel). 2021 Mar 20;14(3):281 – read more
• Faiq MA. et al. Cholinergic nervous system and glaucoma: From basic science to clinical applications. Prog Retin Eye Res. 2019 Sep;72:100767 – read more
• Nucci C. et al. Neuroprotective agents in the management of glaucoma. Eye, 2018 May; 32(5):938-945 – read more
• Parisi V. et al. Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function. Current Neuropharmacology, 2018, 16, 919-932 – read more